3D打印钛基植入物表面功能化改性研究进展

作者	单位	邮编
黄雪连^*	1华南理工大学生物医学科学与工程学院,广东广州,511442 2国家药品监督管理局医疗器械技术审评中心,北京,100076	100076
吴琪	3新型生物材料与高端医疗器械广东研究院,广东广州,510000	510000
王会丹	1华南理工大学生物医学科学与工程学院,广东广州,511442 2国家药品监督管理局医疗器械技术审评中心,北京,100076	100076
卢麒吉^*	1华南理工大学生物医学科学与工程学院,广东广州,511442	511442
张家振^*	2国家药品监督管理局医疗器械技术审评中心,北京,100076	100076

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中文摘要:

医用钛基植入物因其优异的力学性能和良好的生物相容性，被广泛应用于骨科和口腔医学领域。利用3D打印技术可以构建具有多孔结构的钛基植入物，有助于增强材料与骨组织之间的嵌合能力。然而，多孔钛基植入物在临床应用中仍面临骨整合效果有待进一步提升、血管化程度有待增强以及存在术后感染风险等问题，因此有必要通过表面功能化改性对3D打印钛基植入物进一步优化其生物性能。本文综述了传统静态表面改性、新型智能响应涂层改性、免疫调节改性等在3D打印钛基植入物的研究进展，以期为推动新型表面改性策略在相关领域的技术优化与转化应用提供参考。

英文摘要:

Medical Titanium-based implants are widely used in orthopedics and dentistry due to their excellent mechanical properties and good biocompatibility. 3D printing technology enables the construction of porous Titanium-based implants, which enhances interlocking capability between the material and bone tissue. However, porous Titanium-based implants still face challenges in clinical applications, including the need for further improvement in osseointegration efficacy, enhanced vascularization, and the risk of postoperative infection. Therefore, it is necessary to further optimize their biocompatibility through surface functionalization modification. This review summarizes the research progress of traditional static surface modification, novel intelligent responsive coating modification, and immunomodulatory modification strategies for 3D-printed Titanium-based implants. It aims to provide insights for the application and optimization of emerging surface modification strategies in this field, as well as to offer insights into the future development and product applications of related research.

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