| 滑膜炎颗粒在膝关节单髁置换术后应用的疗效分析 |
| Efficacy analysis of the application of Huamoyan Granules after unicompartmental knee arthroplasty |
| 投稿时间：2025-08-26 |
| DOI：10.3969/j.issn.1672-5972.2026.04.010 |
| 中文关键词: 滑膜炎颗粒 骨关节炎 膝关节单髁置换术 术后 |
| 英文关键词:Huamoyan Granules Osteoarthritis, knee Unicompartmental knee arthroplasty Postoperative period |
| 基金项目:保定市科技计划项目（2341ZF330） |
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| 中文摘要: |
| 目的 探讨滑膜炎颗粒在膝关节单髁置换术后应用的临床疗效。方法 选取河北大学附属医院于2023年7月至2024年7月因膝关节骨关节炎行内侧单髁置换术后患者82例，其中应用滑膜炎颗粒患者35例（用药组），未应用患者47例（未用药组），用药组疗程1个月。比较两组患者术前、术后1周疼痛视觉模拟评分（VAS），术前、术后1个月及末次随访膝关节协会评分（KSS），术前及术后3周膝关节活动度（最大屈曲角度、最大伸直角度），术前、术后1周、术后1个月及末次随访的膝关节肿胀程度，以及术前、术后1周血清C反应蛋白（CRP）、红细胞沉降率（ESR）水平。结果 患者均随访6～12个月，平均（8.5±1.8）个月。术后1周，两组VAS评分、膝关节肿胀程度、CRP、ESR均较术前改善，且用药组的VAS评分为（4.03±0.57）分，低于未用药组（5.53±0.65）分，差异有统计学意义（P＜0.05）；用药组的膝关节肿胀程度为（4.02±1.45）cm，小于未用药组（5.16±1.23）cm，差异有统计学意义（P＜0.05）；用药组的CRP、ESR分别为（14.36±1.01）mg/L、（39.03±2.17）mm/h，均低于未用药组（15.44±1.30）mg/L、（43.06±3.13）mm/h，差异均有统计学意义（P＜0.05）。术后3周，两组膝关节最大屈曲角度均大于术前，且用药组为（118.98±11.52）°，大于未用药组（110.81±12.96）°，两组间比较差异有统计学意义（P＜0.05）；两组膝关节最大伸直角度均小于术前，且用药组为（8.18±3.37）°，小于未用药组（11.19±3.81）°，两组间比较差异有统计学意义（P＜0.05）。术后1个月，用药组的KSS评分为（82.71±2.50）分，高于未用药组（75.09±2.29）分，差异有统计学意义（P＜0.05）；用药组膝关节肿胀程度为（1.51±0.79）cm，未用药组为（1.68±0.88）cm，两组差异无统计学意义（P＞0.05）。末次随访时，两组KSS评分比较，差异无统计学意义（P＞0.05）。结论 膝关节UKA术后应用滑膜炎颗粒可降低术后早期疼痛及炎症反应，改善术后膝关节功能与活动度，促进早期康复，且未观察到与药物相关的严重不良反应，但对术后3个月及以上的后续膝关节功能无显著改善作用。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of Huamoyan Granules after unicompartmental knee arthroplasty (UKA).Methods A total of 82 patients who underwent medial UKA for knee osteoarthritis (KOA) at Affiliated Hospital of Hebei University from July 2023 to July 2024 were selected. Among them, 35 patients received Huamoyan Granules (medication group) for a course of 1 month, while 47 patients did not (non-medication group). The visual analogue scale (VAS) score at pre-operation and 1 week post-operation, the Knee Society Score (KSS) at pre-operation, 1 month post-operation, and the last follow-up, knee range of motion (maximum flexion angle, maximum extension angle) at pre-operation and 3 weeks post-operation, knee swelling degree at pre-operation, 1 week post-operation, 1 month post-operation, and the last follow-up, as well as serum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) at pre-operation and 1 week post-operation, were compared between the two groups.Results The patients were followed-up for 6-12 months, with an average of (8.5±1.8) months. At 1 week post-operation, VAS scores, knee swelling degree, CRP, and ESR improved in both groups compared to pre-operative levels. The medication group showed significantly lower VAS scores (4.03±0.57 vs. 5.53±0.65), reduced knee swelling (4.02±1.45 cm vs. 5.16±1.23 cm), and lower CRP (14.36±1.01 mg/L vs. 15.44±1.30 mg/L) and ESR (39.03±2.17 mm/h vs. 43.06±3.13 mm/h) compared to the non-medication group (all P<0.05). At 3 weeks post-operation, knee maximum flexion angle improved in both groups versus pre-operation. The medication group achieved a greater flexion angle (118.98±11.52°) than the non-medication group (110.81±12.96°), and a smaller extension lag (8.18±3.37° vs. 11.19±3.81°) (all P<0.05). At 1 month post-operation, the KSS was significantly higher in the medication group (82.71±2.50) than in the non-medication group (75.09±2.29) (P<0.05). However, no significant difference was found in knee swelling degree between the two groups (1.51±0.79 cm, 1.68±0.88 cm, P>0.05), and no drug-related adverse events occurred during the medication period. At the last follow-up, no significant difference in KSS was observed between the two groups (P>0.05).Conclusion The application of Huamoyan Granules after UKA can reduce early postoperative pain and inflammatory response, improve knee function and range of motion, and promote early rehabilitation with no severe drug-related adverse events observed. However, it does not provide significant additional improvement in mid-term knee function at 3 months or longer post-operation. |
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