淫羊藿苷介导的信号通路对骨关节炎的治疗

作者	单位	邮编
雷卓林^*	十堰市人民医院（湖北医药学院附属十堰市人民医院）创伤骨科,湖北十堰,442000	442000
张晶源	十堰市人民医院（湖北医药学院附属十堰市人民医院）创伤骨科,湖北十堰,442000	442000
曹洪^*	十堰市人民医院（湖北医药学院附属十堰市人民医院）创伤骨科,湖北十堰,442000	442000

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中文摘要:

骨关节炎是最常见的慢性退行性疾病，严重危害患者的生命健康，但由于其病理机制复杂，骨关节炎的基础研究和诊疗都面临着诸多困难和挑战。中草药在抗骨关节炎方面的作用及机制已成为近年来的研究热点，其中淫羊藿苷作为一种极具潜力的抗骨关节炎中草药提取物，具有较高的临床研究价值。淫羊藿苷是从中草药淫羊藿中提取的一种异戊烯基黄酮醇苷类化合物，具有消炎、抗骨质疏松、补肾壮阳、促进造血等多种药理活性。已有研究表明，淫羊藿苷可通过Wnt/β-catenin信号通路、NF-κB信号通路、JAS/STAT信号通路、MAPK信号通路等抑制炎症因子（IL-1、IL-6、TNF-α等）释放、MMPs及ADAMTS的合成缓解骨关节炎的进展。因此，本研究从分子生物学方面进一步阐明淫羊藿苷影响软骨细胞、细胞外基质、滑膜等生物学行为的机制，为关节炎的治疗提供新的思路和方向。

英文摘要:

Osteoarthritis (OA) is the most common chronic degenerative joint disease, posing a serious threat to patients' health and quality of life. However, due to its complex pathological mechanisms, both fundamental research and clinical management of OA face numerous challenges. In recent years, the role and mechanisms of traditional Chinese herbal medicines in combating OA have become a research hotspot. Among them, icariin, a promising bioactive compound derived from the herb Epimedium, has garnered significant attention for its potential clinical applications.Icariin is a prenylated flavonol glycoside isolated from Epimedium species, exhibiting diverse pharmacological properties, including anti-inflammatory, anti-osteoporotic, kidney-tonifying, aphrodisiac, and hematopoietic effects. Previous studies have demonstrated that icariin alleviates OA progression by modulating multiple signaling pathways, such as Wnt/β-catenin, NF-κB, JAK/STAT, and MAPK, thereby suppressing the release of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-α) and inhibiting the synthesis of matrix metalloproteinases (MMPs) and ADAMTS.This study aims to further elucidate the molecular mechanisms by which icariin influences chondrocytes, extracellular matrix, and synovium, providing novel insights and directions for OA therapy.

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