| 刺激响应性材料治疗骨髓炎的研究进展 |
| Research progress of stimulus-responsive materials in the treatment of osteomyelitis |
| 投稿时间：2024-06-06 |
| DOI：10.3969/j.issn.1672-5972.2025.03.016 |
| 中文关键词: 骨髓炎 感染 刺激响应 抗菌治疗 纳米材料 |
| 英文关键词:Osteomyelitis Infection Stimulus response Antimicrobial therapy Nanomaterials |
| 基金项目:湖北省科技计划立项项目（2022BCE003） |
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| 中文摘要: |
| 骨髓炎是一种严重的深部组织感染性疾病，传统治疗方法效果不佳且副作用大。近年来，刺激响应性材料作为一种新型治疗手段备受关注。这些材料能根据体内感染部位的微环境变化、生物学信号或体外物理化学刺激，释放抗菌活性物质，实现高度的靶向治疗和更广泛的应用前景。通过综合回顾和分析刺激响应性抗菌材料的最新研究成果，旨在为未来更有效治疗骨髓炎疾病提供新思路，为患者提供更好的治疗效果。 |
| 英文摘要: |
| Osteomyelitis is a serious deep tissue infection for which traditional treatments often yield limited efficacy and significant side effects. In recent years, stimulus-responsive materials have attracted considerable attention as innovative therapeutic agents. These materials can release antimicrobial agents in response to changes in the microenvironment of the infection site, biological signals, or external physicochemical stimuli, enabling highly targeted treatment and broad application prospects. This article provides a comprehensive review and analysis of recent research on stimulus-responsive antimicrobial materials. The aim is to provide new insights for the development of more effective treatment strategies for osteomyelitis, thereby significantly improving patient outcomes. |
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