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基于水凝胶体系修复脊髓损伤的研究进展
Research progress of repairing spinal cord injury based on hydrogel system
投稿时间:2024-01-08  
DOI:10.3969/j.issn.1672-5972.2024.06.014
中文关键词:  脊髓损伤  水凝胶  导电生物材料  干细胞移植
英文关键词:Spinal cord injury  Hydrogel  Conducting biomaterials  Stem cell transplantation
基金项目:广东省自然科学基金项目(2022A1515010307);广州市科技计划项目(2023A03J0693)
作者单位邮编
张北辰 中国人民解放军南部战区总医院骨科广东 广州510010
广州中医药大学研究生院广东 广州510405 
510405
张涛* 中国人民解放军南部战区总医院骨科广东 广州510010
广州中医药大学研究生院广东 广州510405 
510405
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中文摘要:
      脊髓损伤(spinal cord injury, SCI)是一种严重的中枢神经系统疾病,可导致运动和感觉功能的丧失。由于其复杂的病理机制,目前该病的治疗仍面临巨大的挑战。水凝胶凭借其良好的生物安全性和对脊髓微环境中细胞外基质的模拟性,在SCI修复领域中展现出巨大潜力。大量研究表明,水凝胶治疗体系可有效降低SCI损伤部位炎症水平,促进脊髓修复和神经再生,改善SCI模型的运动功能恢复。本文综述了常见水凝胶的理化特征、生物学性能及水凝胶治疗脊髓损伤的多种治疗策略,并讨论了水凝胶支架联合其他治疗方式在SCI中的治疗效果。
英文摘要:
      Spinal cord injury (SCI) is a severe central nervous system disorder that can result in the loss of motor and sensory functions. Due to its complex pathophysiology, the treatment of this condition remains a major challenge. Hydrogels, with their excellent biocompatibility and ability to mimic the extracellular matrix in the spinal cord microenvironment, have shown tremendous potential in the field of SCI repair. Numerous studies indicate that hydrogel treatment systems can effectively reduce inflammation levels at the SCI injury site, promote spinal cord repair and nerve regeneration, and enhance the recovery of motor functions in SCI models. This article reviews the physicochemical characteristics and biological properties of common hydrogels, as well as different therapeutic strategies for treating spinal cord injury with hydrogels. Additionally, it discusses the treatment outcomes of hydrogel scaffolds combined with other therapeutic approaches in the context of SCI.
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