| 氧化应激引发椎间盘退变的作用机制 |
| Mechanism of oxidative stress inducing intervertebral disc degeneration |
| 投稿时间：2023-06-21 |
| DOI：10.3969/j.issn.1672-5972.2024.04.016 |
| 中文关键词: 椎间盘退变 氧化应激 机制 信号通路 |
| 英文关键词:Intervertebral disc degeneration Oxidative stress Mechanism Signaling pathway |
| 基金项目: |
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| 中文摘要: |
| 下腰痛是临床上最常见的肌肉骨骼系统疾病之一。椎间盘退变是导致下腰痛发生的主要原因。近年来的研究发现，氧化应激是引起椎间盘退变的主要致病因素之一。氧化应激可导致一系列与该疾病相关的病理生理改变，包括椎间盘的炎症反应、细胞外基质降解、细胞衰老和凋亡等。因此，本文将对由氧化应激引起椎间盘退变的内在作用机制进行综述，为寻找治疗该问题的方式提供理论依据。 |
| 英文摘要: |
| Low back pain is a prevalent musculoskeletal disorder encountered in clinical practice, with intervertebral disc degeneration being the primary underlying cause. Recent studies have elucidated that oxidative stress plays a pivotal role in the pathogenesis of intervertebral disc degeneration. Oxidative stress triggers a cascade of pathological alterations associated with this condition, including inflammation within the intervertebral discs, degradation of the extracellular matrix, cellular senescence, and apoptosis. Consequently, this article aims to comprehensively review oxidative stress-induced intervertebral disc degeneration and to establish a theoretical basis for identifying potential therapeutic strategies. |
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