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间充质干细胞来源的外泌体对脊髓损伤中神经元铁死亡调控的研究进展
Research progress on the regulation of neuronal ferroptosis in spinal cord injury by mesenchymal stem cell-derived exosomes
投稿时间:2023-07-04  
DOI:10.3969/j.issn.1672-5972.2024.03.012
中文关键词:  脊髓损伤  铁死亡  间充质干细胞  外泌体
英文关键词:Spinal cord injury  Ferroptosis  Mesenchymal stem cell  Exosomes
基金项目:
作者单位邮编
刘宇 南京医科大学附属江宁医院骨科江苏 南京211100 211100
刘新晖* 南京医科大学附属江宁医院骨科江苏 南京211100 211100
殷建* 南京医科大学附属江宁医院骨科江苏 南京211100 211100
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中文摘要:
      脊髓损伤(spinal cord injury, SCI)是一种破坏性的神经系统疾病,严重影响患者的感觉、运动和自主神经功能,目前缺乏有效的治疗手段。铁死亡作为一种非凋亡的铁依赖性细胞死亡机制,可能在脊髓损伤中发挥重要作用。外泌体是一种直径为30 ~ 150 nm的细胞外囊泡,包含mRNA、miRNA和蛋白质等功能性小分子,被认为是细胞间交流的关键介质。近年来越来越多的学者关注到,间充质干细胞来源的外泌体(mesenchymal stem cell-derived exosomes, MSC-Exos)在脊髓损伤治疗中发挥抑制炎症和促进轴突再生的作用。诸多研究发现MSC-Exos在调节脊髓损伤中神经元铁死亡方面具有巨大潜力。本文主要综述了铁死亡的分子机制,并探讨了MSC-Exos通过抑制神经元铁死亡治疗脊髓损伤的可能性。
英文摘要:
      Spinal cord injury (SCI) is a destructive disease of the nervous system that seriously impairs the sensory, motor and autonomic nervous functions of patients, and currently lacks an effective treatment. Ferroptosis as a non-apoptotic iron-dependent cell death mechanism may play an important role in SCI. Exosomes are extracellular vesicles with a diameter of 30-150 nm, that contain functional small molecules such as mRNA, miRNA and proteins. They have been recognized as key mediators of communication between cells. In recent years, more and more attention has been paid to the role of mesenchymal stem cell-derived exosomes (MSC-Exos) in the treatment of spinal cord injury to inhibit inflammation and promote axon regeneration, and many studies shows that MSC-Exos have great potential in the treatment of spinal cord injury caused by ferroptosis. This article mainly elucidates the mechanism of cell ferroptosis and explores the strategy of MSC-Exos in treating SCI by inhibiting neuronal ferroptosis.
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