| Artificial bone graft substitutes belong to a novel interdisciplinary field established with innovation and fusion of medical science, materials science, life science, and so on in recent hundred years. In this field, the knowledge and theoretical systems have been being constantly developed, and related technologies and products have been being rapidly improved and upgraded. Compared to conventional autologous, allogeneic, or xenogeneic bone grafts, artificial bone graft substitutes possess obvious advantages of unlimited sources, adjustable physical and chemical properties, low immune rejection and disease transmission risks. Biocompatibility,biomimetic properties,osteoconductivity, and osteoinductivity of the materials are continuously improved and approaching the natural bone and therefore artificial bone graft substitutes are gradually becoming one of the major options for bone grafting in clinical applications. This review analyzes the actual needs of clinical bone grafting in China, summarizes the development characteristics of bone repair materials, relevant products and clinical application status in China, describes in detail the classification and performance characteristics of synthetic bone repair materials, and introduces in detail the clinical application of several typical synthetic bone repair materials in many medical fields, and concluded and prospected the future technical development path of synthetic bone repair materials. |
