| The increasing number of bone defects caused by various causes such as tumors, trauma or other diseases is becoming a global problem. Although existing bone tissue engineered graft materials can meet the needs of bone transplantation to a certain extent, the ability of osteoinduction of most materials is not satisfactory. Hydroxyapatite(HA) has always been a classic base material for bone tissue engineering due to its good ability to induce bone defect repair. However, the ability of traditional HA materials to induce bone regeneration is still limited. Therefore, how to effectively modify HA has become a major issue. This paper reviews the research progress of metal doped HA and its effect on bone regeneration. It also provides a new way of thinking to solve the increasing demand of bone defect implantation. |
