聚醚醚酮基骨科植入物的改性技术研究

目的结合聚醚醚酮（PEEK）、聚乳酸（PLA）和硫酸软骨素锶（SrCS）各自的优势，制备出易加工、与松质骨力学性能匹配且兼具生物活性的聚醚醚酮基生物材料。方法将熔融的PLA充分地填充在PEEK二维编织结构孔隙中，通过热压制备PLA/PEEK复合材料，并对其表面形貌和结构、结晶度、宏观和微观力学强度进行研究。随后在最优力学性能的PLA/PEEK复合材料中引入SrCS并使其与细胞共培养，通过MTT法评价细胞在复合材料上的增殖情况。结果在155℃和10 MPa的热压条件下，PLA与PEEK细丝结合致密并形成了互锁结构，所得PLA/PEEK复合材料具有与松质骨相似的抗断裂性能、弹性模量和多尺度力学特性。SrCS的引入对复合材料的力学特性进行了微调，并显著提升其生物活性。结论 PLA和SrCS的引入可以有效地改善PEEK基材料的可加工性和生物活性，且结构互锁的PLA/PEEK复合材料具有仿松质骨的力学特性，因此SrCS/PLA/PEEK复合材料有潜力作为新型的骨科修复材料。

英文摘要:

Objective To prepare polyetheretherketone-based biomaterials which were easy to process, matched with the mechanical properties of cancellous bone and had biological activity by taking the advantages of polyetheretherketone (PEEK), polylactic acid (PLA) and strontium chondroitin sulfate (SrCS). Methods The molten PLA was filled into two-dimensional braided PEEK to prepare a new PLA/PEEK composite, and the surface morphology, crystallinity, macro- and micro- mechanical strength was investigated. Subsequently, SrCS was introduced into the PLA/PEEK composite with the best mechanical properties. The proliferation of SrCS/PLA/PEEK composite was evaluated by cocultured the cells with materials. Results PLA and PEEK filaments combined densely and formed an interlocking structure under the conditions of 155°C and 10 MPa hot pressing, which led to the optimal fracture resistance, elastic modulus and multiscale mechanical behavior of PLA/PEEK composites as similar as those of cancellous bone. The incorporation of SrCS improved the bioactivity of PLA/PEEK composites. Conclusion The introduction of PLA and SrCS can effectively improve the processability and biological activity of PEEK-based materials and the PLA/PEEK composite with structural interlocking possesses mimic mechanical properties of cancellous bone. Therefore, the SrCS/PLA/PEEK composite has the potential to be used as new orthopedic repair materials.

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