| Large bone defects secondary to various causes usually need to repair with artificial bone materials, the commonly used artificial bone materials include artificial bone-based calcium phosphate and calcium sulfate substrate, bioactive glass and so on. The artificial bones with calcium phosphate as the main component, combined with one or more other materials in order to improve the performance of artificial bones has become a hot topic in current research. In this paper, we will summarize the research progress of various kinds of composites with based calcium phosphate substrate in bone defect repair, including composite with polymer, alloy material, drug sustained release and bone tissue engineering material, to provide the basis for the related research of calcium phosphate artificial bone. |
