| Regeneration and repair of large bone defects is one of the problems in clinical orthopedics. The use of tissue engineering materials to repair large bone defects is the most promising treatment method. β-TCP material has similar inorganic components compared to human bone, good biocompatibility, absorption and degradation, and bone conduction properties. It is widely used in orthopedic clinical treatment. Although β-TCP material is one of the most potential bone replacement materials, it still has defects such as mismatch between degradation rate and new bone regeneration rate, insufficient brittle mechanical strength, and poor osteoinduction capacity, which hinder the clinical application. Modification of the β-TCP materials with other materials to improve degradation, mechanics, and osteoinductive properties are the current research focus.The application of β-TCP materials modification in the regeneration of bone defects was reviewed in this article. |
