Objective To explore the clinical effect of 3D printing assisted external fixator in the treatment of complex bone defects of lower limbs. Methods Data of 12 cases of lower extremity complex bone defects admitted from January 2017 to December 2018 were retrospectively analyzed. There were 7 males and 5 females, aged from 12 to 48 years, with an average age of 32 years. The 12 cases were divided into 3D group and traditional group, 6 cases each. The Fugl-Meyer evaluation scale was used to evaluate the efficacy of the patients, and the obtained data were statistically analyzed by SPSS 19.0 software. Results All patients were followed up for 6 to 12 months (mean 8 months). There was no significant difference between the 3D group and the traditional group in terms of age, gender, moving time, callus mineralization time and HSS knee function score (P>0.05), while the difference in operation time, intraoperative blood loss and fluoroscopy frequency between the two groups was statistically significant (P<0.05). According to the Fugl-Meyer evaluation scale, the efficacy of patients in the 3D group was evaluated higher than that in the traditional group (P<0.05). Conclusion The application of 3D printing technology can make the preoperative plan in advance and perform the operation preview, making the operation more accurate and minimally invasive. Patients with good postoperative compliance and high satisfaction can obtain better postoperative results. reinforcer and study the oxidative stress of PEEK/SPEEK/HA biomaterial on bone environment cells. Methods Osteoblasts MG-63 cells and fibroblasts 3T3 cells were selected as the research objects to compare the effects of biomaterials on ROS and MDA levels of the two kinds of cells and to observe the growth morphology of the two kinds of cells on PEEK/SPEEK/30% HA materials. Results The oxidative stress level of MG-63 cells and 3T3 cells increased when cultured on PEEK and SPEEK materials, but PEEK/HA was lower than PEEK and SPEEK materials. Compared with PEEK materials, SPEEK materials can reduce the oxidative stress level of cells, PEEK/SPEEK/HA biomaterials made the oxidative stress level of MG-63 cells and 3T3 cells lower than PEEK/HA biomaterials, when the HA content reached 30%, the oxidative stress level of MG-63 cells was close to normal and the growth of the two cells on the surface of the biomaterials was unrestricted. Conclusion The introduction of HA and SPEEK could reduce the oxidative effect of cells. |