| Objective Polyetheretherketone (PEEK) has an elastic modulus similar to the bone; however, its use as a material for bone repair is limited by bio-inert surface and poor osteogenesis-inducing capacity. To address this issue, the PEEK surface was docerated with photoreactive gelatin for enhancing biocompatibility. Methods A photoreactive gelatin (Az-Gel), which could be immobilized on various matrices by UV-irradiated, was synthesized by our group to improve the matrices biocompatibility. The surface characteristics and in vitro cellular behavior are systematically investigated by scanning electron microscopy, static contact angles, cell proliferation assay, alkamine phosphatase activities and cellular morphology. Results Our study demonstrated that Az-Gel was immobilized on the surfaces of PEEK and could change the surface properties of polymer substrates. In vitro experiment, MC3T3-E1 cells showed increased proliferation, cell spreading, cellular matrix secretion and osteogenic differentiation capacity on Az-Gel -modified as compared to unmodified PEEK. Conclusion PEEK that surface-modified with photoreactive gelatin can enhance biocompatibility and is a potential material for use in orthopedic implants and medical devices. |
