| Objective To investigate the difference of bone healing and the callus formation rate between bone fracture combined traumatic central nervous system injury and simple bone fracture through Meta-analysis and prove that traumatic central nervous system can accelerate bone fracture healing. Methods The databases of PubMed, EMbase, VIP, CNKI and WanFang Database were retrieved with computer (until Nov, 2017) for searching the cohort studies related to the correlation between traumatic central nervous system injury and bone fracture healing, the references of those researches were also searched by hand. All documents were read and screened strictly according to exclusion criteria. The data were extracted and given a Meta-analysis. Results There were totally 9 studies included involving 636 cases (all researches are about traumatic brain injury) . The Meta-analysis showed that① the time of bone fracture healing of traumatic brain injury fracture group is significantly shorter [SMD=-1.43,95%CI(-2.03，-0.83), P＜0.00001]than that of simple fracture group. ② the callus formation rate of simple fracture group on 4, 8, 12 weeks are significantly lower[RR=3.19, 95%CI(1.62, 6.28), P=0.0008]、[RR=3.08, 95%CI(1.90, 5.00), P＜0.00001]、[RR=1.78, 95%CI(1.42, 2.23), P＜0.00001] than that of traumatic brain injury fracture group. ③ the amount of callus of simple fracture group on 4, 8 weeks were significantly lower[MD=1.42, 95%CI(1.38, 1.46), P＜0.00001]、[MD=1.20, 95%CI(1.19, 1.21), P＜0.00001]、[MD=1.50, 95%CI(1.46, 1.54), P＜0.00001]、[MD=1.24, 95%CI(1.23, 1.26), P＜0.00001] than that of traumatic brain injury fracture group. Conclusion Traumatic central nervous system injury can accelerate bone fracture healing. |
