| miR-564在关节软骨损伤修复中作用机制的研究进展* |
| Research progress on functional mechanisms of miR-564 on articular cartilage injury and repair |
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| DOI： |
| 中文关键词: miR-564 关节软骨损伤 修复 |
| 英文关键词:miR-564 Articular cartilage injury Repair |
| 基金项目: |
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| 通讯作者:孙祥燚1 赵建宁2 周利武2 徐海栋2 张雷2* |
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| 中文摘要: |
| 关节软骨损伤修复一直是关节外科的热点和难点，最新研究表明，miR-564可能在关节软骨损伤修复中起着至关重要的作用。miR-564是位于第3号染色体上的非编码RNA，其功能主要是通过影响mRNA的稳定性和翻译进而参与基因表达的转录后调节，因此未来有望通过调控miR-564实现关节软骨损伤的原位修复。本文就miR-564的结构、功能及在关节软骨损伤修复中的作用机制作一综述。 |
| 英文摘要: |
| The repair of articular cartilage injury has always been a hot and difficult spot in the department of joint surgery. Recent studies have shown that miR-564 plays a key role in the repair of articular cartilage injury. miR-564 is a non-coding RNA located on chromosome 3, which is mainly involved in the post-transcriptional regulation of gene expression by influencing the stability and translation of mRNA. Therefore, it is expected that miR-564 will achieve the effect of articular cartilage injury repair. In this paper, the structure and function of miR-564 and the mechanism of repair of articular cartilage injury were reviewed. |
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